Gao & Eshaghi 2021, omega-3 and exercise-induced muscle damage markers

A meta-analysis of 10 RCTs found that omega-3 supplementation significantly reduced three indirect blood markers of exercise-induced muscle damage: creatine kinase (WMD −146.30 IU/L, 95% CI −214.93 to −77.67, p < 0.001), lactate dehydrogenase (WMD −96.20 IU/L, 95% CI −148.07 to −44.32, p < 0.001), and myoglobin (WMD −61.49 ng/mL, 95% CI −86.63 to −36.35, p < 0.001). Effects on CK were strongest at 48 hours post-exercise; myoglobin peaked at 72 hours. Effects were more pronounced in untrained participants after more than one month of supplementation. Moderate evidence.